Understanding Telomeres “The Guardians of Youth“
In the quest for eternal youth, scientists have long been fascinated by telomeres, the protective caps at the end of chromosomes that play a crucial role in cellular aging. As our understanding of telomeres deepens, so too does our appreciation for their impact on skin health and aging. In this blog post, I explore the fascinating world of telomeres, their effect on skin cells, and the many skin health benefits of a cosmetic ingredient known as Geranylgeranylisopropanol (GGP), supported by scientific research and references.
Telomeres are repetitive DNA sequences located at the ends of chromosomes, akin to the plastic tips on shoelaces that prevent them from unraveling. Their primary function is to protect the integrity of chromosomes during cell division by preventing them from deteriorating or fusing with neighboring chromosomes. Our skin cell DNA contains a string of amino acids called telomeres.
With each cell division, telomeres naturally shorten, acting as a cellular clock that limits the number of times a cell can replicate. Once telomeres become critically short, cells enter a state of senescence or undergo apoptosis (cell death), contributing to the aging process and decline in skin tissue function.
- Short Telomere = Deteriorated skin cells appear older
- Longer Telomeres = Healthier skin cells, younger looking skin
The discovery of how chromosomes are protected by Telomeres was awarded the Nobel Prize in Physiology or Medicine to Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak in 2009.
Press release. NobelPrize.org. 2009.
The Role of Telomeres in Skin Aging
In the context of skin aging, telomeres play a significant role in maintaining the vitality and regenerative capacity of skin cells. Every time a cell divides, chromosomes become shorter. Since the ends of the chromosomes are protected by telomeres, the only part of the chromosome that loses bases (about 25 to 200) is the end of the telomere and the rest of the DNA is left undamaged. Without the telomeres, important parts of the chromosome would be lost every time a cell undergoes DNA replication, which is generally around 50 to 70 times.
In younger cells, an enzyme called telomerase prevents telomeres from losing too many bases by adding the TTAGGG repeat back to the ends of chromosomes. However, as a cell repeatedly divides, telomerase becomes less able to keep up with the number of bases that need adding and the telomeres start to shorten as the cell ages.
As telomeres shorten with age, skin cells experience reduced proliferation and regeneration, leading to thinning of the epidermis the outer layer of your skin, loss of skin elasticity, and the formation of wrinkles and fine lines.
Additionally, external factors such as UV radiation, pollution, and oxidative stress can accelerate telomere shortening, further exacerbating the aging process and compromising skin health.
GGP A Potent ProAging Skin Ally
Geranylgeranylisopropanol (GGP) is a cosmetic ingredient derived from geranylgeraniol, a natural compound found in certain plants. GGP is believed to exert its pro-aging effects by targeting telomere shortening and promoting cellular longevity. Here’s how GGP may benefit the skin:
- Telomere Protection: GGP has been shown to protect telomeres from premature shortening induced by oxidative stress and other external aggressors. By preserving telomere length, GGP helps maintain the replicative capacity of skin cells and supports their longevity.
- Cellular Regeneration: Studies suggest that GGP enhances the proliferation and regenerative potential of skin cells, promoting tissue repair and rejuvenation. By stimulating cellular turnover, GGP contributes to a more youthful, radiant complexion.
- Antioxidant Activity: GGP exhibits antioxidant properties, scavenging free radicals and reducing oxidative damage to skin cells. By neutralising harmful reactive oxygen species (ROS), GGP helps protect against premature aging and maintains skin health.
- Collagen Synthesis: GGP has been shown to stimulate collagen synthesis in the skin, promoting firmness, elasticity, and overall skin tone. By enhancing collagen production, GGP helps minimise the appearance of wrinkles and fine lines, resulting in smoother, more youthful-looking skin.
- Skin Tone: Evens skin tone by fading redness and age spots.
Backed By Science With Clinical Trials
In vitro (in a lab) tests performed with GGP have demonstrated it’s efficiency:
- Reduces oxidative stress – Production of intracellular peroxides reduced by 85%
- Limits telomere (DNA) shortening – Ensuring optimal replication as a young cell
- Rebalances the mitochondrial activity – An important part of healthy skin
- Promotes ATP synthesis +76% – Protects the cytoskeleton which is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells including skin
- The extracellular matrix metabolism is reactivated boosting collegen and hyaluronic acid synthesis
- Collagen Type I synthesis +483% – Type I is the major form of collagen found in the dermis, providing tensile strength in the skin
- Decorin Synthesis +32% – Helps to constitute extracellular matrix in collagen-containing tissues i.e the skin
- Hyaluronic acid synthesis +33% – The key molecule involved in skin moisture is hyaluronic acid that has unique capacity in retaining water keeping your skin hydrated
- Increased protection against peroxidation of the skin by up to 85% – Helping maintain the protective effect of the skin barrier.
In vivo (on human skin) tests were carried out on 28 female volunteers have shown that:
- Helps to reduce the visible signs of aging on the face and décolleté
- Smoothes fine lines/wrinkles, restructures and redensifies the skin
- After just one month of treatment, the main wrinkle depth is decreased by 26.5%
- 80% of the panel consider that their skin is less creased and much firmer after a 2-month treatment
- 93% said they experienced more hydration overall.
The Role of ATP synthesis And Skin Health
Your skin is a high turnover organ, on average, it takes an estimated 40 to 56 days for your epidermis to completely turn over, but that timeline only lengthens as we age, and it’s constant renewal depends on the rapid proliferation of its Epidermis Stem Cells. The energy requirement for these active cells is met by mitochondrial respiration, an ATP generating process driven by a series of proteins. Mitochondria have important roles in skin function, and mitochondrial damage has been found to accumulate with age in skin cells, but also in response to solar light and pollution. There is increasing evidence that mitochondrial dysfunction and oxidative stress are key features in all aging tissues, including skin.
As skin is constantly defending against environmental insult, it is important to maintain its integrity: aging skin has reduced wound healing capacity and increased water loss. This increases susceptibility to cuts and infection, and makes it more prone to irritation and skin conditions that cause inflammation of the skin, such as eczema (known as dermatitis.) It is essential to maintain an adequate skin barrier.
Protect, Prevent and Rejuvenate
LUCA Lipid Ferment Vitamin C Serum contains The High Performance Active Juvinity™ a revolutionary skincare breakthrough incorporating enhanced telomeres technology, inspired by Nobel Prize Telomeres Innovation and designed to reverse the visible effects of the aging skin cells. Juvinity™ is proven to prolong the life of a skin cell, thus reducing the visible effects of skin aging.
- Preserving telomere health is important as you age, and can help preserve the youthful appearance of your skin
- Telomeres are the end caps of chromosomes and important in the cellular replication process
- Telomeres can get shorter and shorter as you age, losing their ability to protect your DNA from the effects of aging
- Geranylgeranylpropanol is a substance that helps protect your skin telomeres better than any other cosmetic ingredient currently available, and it’s found in a patented substance called Juvinity™.
- Antioxidants Vitamins C and E are known for their telomere-protective properties, these are both included in the formulation of LUCA Lipid Ferment Vitamin C Serum. You can read “How To Minimise UV Skin Damage With Vitamin C” on our Holistic Wellness Matters Blog.
SHOP LUCA Lipid Fermet Vitamin C Serum
Conclusion
By protecting telomeres, stimulating cellular regeneration, providing antioxidant protection, and enhancing collagen synthesis, the topical application of the GGP substance holds the potential to rejuvenate the skin, diminish wrinkles, and restore a youthful complexion. Incorporating LUCA Lipid Ferment Vitamin C Serum enriched with Juvinity™ (GGP) into your (idealy morning) daily skin selfcare ritual, offers an holistic, proactive approach to combating the signs of aging and maintaining radiant, healthy skin for years to come – your future skin will thank you!
Until next time, be human, be kind, be you.
REFERENCES:
- Harlyk, Christopher, et al. “Composition for cosmetic use comprising geranylgeranyl-propanol and methods.” U.S. Patent Application No. 11/763,495, filed June 15, 2007.
- Jang, Ji-Eun, et al. “A Novel Geranylgeranyl Isopropanol that Diminishes UV-Induced Wrinkle Formation and DNA Damage.” Journal of Dermatological Science, vol. 70, no. 3, 2013, pp. 204-211.
- Hsu, J., et al. “Geranylgeranyl isopropanol alleviates the progression of age-related skin degeneration through enhancing cellular survival.” Journal of Cosmetic Dermatology, vol. 17, no. 2, 2018, pp. 191-197.
- Sreedhar A, Aguilera-Aguirre L, Singh KK. Mitochondria in skin health, aging, and disease. Cell Death Dis. 2020 Jun 9;11(6):444. doi: 10.1038/s41419-020-2649-z. PMID: 32518230; PMCID: PMC7283348.
- Stout R, Birch-Machin M. Mitochondria’s Role in Skin Ageing. Biology (Basel). 2019 May 11;8(2):29. doi: 10.3390/biology8020029. PMID: 31083540; PMCID: PMC6627661.
- Koster MI. Making an epidermis. Ann N Y Acad Sci. 2009 Jul;1170:7-10. doi: 10.1111/j.1749-6632.2009.04363.x. PMID: 19686098; PMCID: PMC2861991.
- Cavallasca J. The central role of stem cells and telomeres in the aging process. Long Life, 2017.